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         Originalarbeiten 2016:
         Übersichtsarbeiten 2016:
 
 


  • Berg, D., Stühmer, T., Siegmund, D., Müller, N., Giner, T., Dittrich-Breiholz, O., Kracht, M., Bargou, R., and Wajant, H. (2009). Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways. FEBS J., 276:6912-27.

  • Wicovsky, A., Salzmann, S., Roos, C., Ehrenschwender, M., Rosenthal, T., Siegmund, D., Henkler, F., Gohlke, F., Kneitz, C., and  Wajant, H. (2009). TNF-like weak inducer of apoptosis (TWEAK) inhibits proinflammatory TNF receptor-1 signaling. Cell Death Differ., 16: 1445-1459.

  • Wyzgol A., Müller N., Fick A., Munkel S., Grigoleit GU., Pfizenmaier K.,  and Wajant H. (2009). Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand. J Immunol., 183:1851-61.

  • Wicovsky A., Henkler F., Salzmann S., Scheurich P., Kneitz C., and  Wajant H. (2009). Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation. Oncogene., 28: 1769-1781.

  • Schmidt E., Gutberlet J., Siegmund D., Berg D., Wajant H. and Waschke J. (2009). Apoptosis is not required for acantholysis in pemphigus vulgaris. Am J Physiol Cell Physiol., 296:C162

  •  

    Übersichtsarbeiten 2009:

     Improving TNF as a cancer therapeutic: tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects. Gerspach J, Pfizenmaier K, Wajant H.Biofactors. 2009 Jul-Aug;35(4):364-72. Review.

    Targeted cancer immunotherapy using ligands of the tumor necrosis factor super-family. Bremer E, de Bruyn M, Wajant H, Helfrich W.Curr Drug Targets. 2009 Feb;10(2):94-103. Review.

    Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands. Gerspach J, Wajant H, Pfizenmaier K. Results Probl Cell Differ. 2009;49:241-73. Review.

    The role of TNF in cancer. Wajant H.Results Probl Cell Differ. 2009;49:1-15. Review.

    The Role of FasL and Fas in Health and Disease. Ehrenschwender M, Wajant H.
    Adv Exp Med Biol. 2009;647:64-93.


    Originalarbeiten 2008:

    Stühmer T., Zöllinger A., Siegmund D., Chatterjee M., Grella E., Knop S., Kortüm M., Unzicker C., Jensen MR., Quadt C., Chène P., Schoepfer J., García-Echeverría C., Einsele H., Wajant H.,  and Bargou RC.(2008)
    Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma. Leukemia., 8:1604-12.

    von Langermann J., Guterl JK., Pohl M., Wajant H.,  and Kragl U.(2008)
    Hydroxynitrile lyase catalyzed cyanohydrin synthesis at high pH-values. Bioprocess Biosyst Eng., :155-61.

    Müller N., Wyzgol A., Münkel S., Pfizenmaier K.,  and Wajant H. (2008). Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization. FEBS J., 275:2296-304.

    Egberts JH., Cloosters V., Noack A., Schniewind B., Thon L., Klose S., Kettler B., von Forstner C., Kneitz C, Tepel J., Adam D., Wajant H., Kalthoff H.,  and Trauzold A. (2008). Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis. Cancer Res., 68:1443-50.


    Originalarbeiten 2007:

    Berg, D., Lehne, M., Müller, N., Siegmund, D., Münkel, S., Sebald, W., Pfizenmaier, K., and Wajant, A. (2007) Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L. Cell Death Differ., 14: 2021-2034.

    Siegmund, D., Klose, S., Zhou, D., Baumann, B., Kalthoff, H., Wajant, H., and Trauzold, A. (2007). CD95L and TRAIL induce proinflammatory genes by caspase-dependent but apoptosis-independent activation of NFKB and ERK in Colo357 cells. Cell. Signal., 19: 1172-1184.

    Wicovsky, A., Muller, N., Daryab, N., Marienfeld, R., Kneitz, C., Kavuri, S., Leverkus, M., Baumann, B. and Wajant H. (2007). Sustained JNK activation in response to TNF is mediated by caspases in a cell type-specific manner.
    J. Biol. Chem., 282: 2174-2183.

    Watermann, I., Gerspach, J., Lehne, M., Seufert, J., Schneider, B., Pfizenmaier, K., Wajant, H. (2007). Activation of CD95L fusion protein prodrugs by tumor-associated proteases.Cell Death Differ., 14: 765-774.

    Übersichtsarbeiten 2007:

    The CD95 receptor: apoptosis revisited.
    Peter ME, Budd RC, Desbarats J, Hedrick SM, Hueber AO, Newell MK, Owen LB, Pope RM, Tschopp J, Wajant H, Wallach D, Wiltrout RH, Zörnig M, Lynch DH.
    Cell. 2007 May 4;129(3):447-50.
    PMID: 17482535 [PubMed - indexed for MEDLINE]


    Originalarbeiten 2006:

    Begue, B., Wajant, H., Bambou, J.C., Dubuquoy, L., Siegmund, D., Beaulieu, J.-F., Canioni, D., Berrebi, D., Brousse, N., Desreumaux, P., Schmitz, J., Lentze, M.J., Goulet, O., Cerf-Bensussan, N. and Ruemmele F.M. (2006). Implication of TNF-related apoptosis inducing ligand (TRAIL) in inflammatory intestinal epithelial lesions.
    Gastroenterology, 130: 1962-1974.

    Assohou-Luty, C., Gerspach, J., Siegmund, D., Müller, N., Huard, B., Tiegs, G., Pfizenmaier, K., Wajant, H. (2006). A CD40-CD95L fusion protein interferes with CD40L-induced pro-survival signalling and allows membrane CD40L-restricted activation of CD95.
    J. Mol. Med., 84: 785-797.

    Trauzold, A., Siegmund, D., Schniewind, B., Sipos, B., Egberts, J., Zorenkov, D., Emme, E., Röder, C., Kalthoff, H., and Wajant, H. (2006). TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma.
    Oncogene, 25: 7434-7439.

    Gerspach, J.Nemeth, J., Munkel, S., Wajant, H., and Pfizenmaier, K. (2006). Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface.
    Cancer Immunol Immunother., 55: 1590-1600.

    Gerspach, J., Müller, D., Münkel, S., Selchow, O., Nemeth, J., Noack, M., Menrad, A., Wajant, H. and Pfizenmaier, K. (2006). Restoration of membrane TNF like activity by cell surface targeting and metalloproteinase-mediated processing of a TNF prodrug.
    Cell Death Differ., 13: 273-284.

    Übersichtsarbeiten 2006:

    Wajant, H. TNF receptor / Fas signaling. In "Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine" Springer Verlag, Heidelberg, in press.

    Wajant, H. (2006). CD95L/FasL and TRAIL in tumour surveillance and cancer therapy.
    Cancer Treat Res. 130:141-165.


    Originalarbeiten 2005:

    Wicovsky, A., Siegmund, D. and Wajant H. (2005). Interferons induce proteolytic degradation of TRAILR4.
    Biochem. Biophys. Res. Commun., 337: 184-190.

    Siegmund, D., Wicovsky, A., Schmitz, I., Schulze-Osthoff, K-S., Kreuz, S., Leverkus, M., Dittrich-Breiholz, O., Kracht, M. and Wajant, H. (2005). Death receptor-induced signaling pathways are differentially regulated by interferon-gamma upstream of caspase-8 processing.
    Mol. Cell. Biol., 25: 6363-6379.

    Henkler, F., Behrle, E., Dennehy, KM., Wicovsky, A.,  Peters,N., Warnke,C., Pfizenmaier, K., and  Wajant, H. (2005). The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability.
    J. Cell Biol.,168,1087-1098.

    Trauzold, A., Roder, C., Sipos, B., Karsten, K., Arlt, A., Jiang, P., Martin-Subero, J. I., Siegmund, D., Muerkoster,S., Pagerols-Raluy, L.,Siebert, H., Wajant, H., and Kalthoff, H. (2005). CD95 and TRAF2 promote invasiveness of pancreatic cancer cells.
    Faseb J.,19, 620-622.

    Übersichtsarbeiten 2005:

    Wajant, H., Gerspach, J., and  Pfizenmaier, K. (2005).
    Tumor therapeutics by design: targeting and activation of death receptors.
    Cytokine Growth Factor Rev.,16,55-76.


    Originalarbeiten 2004:

    Chaneva, S., Schneider, G., Siegmund, D., Wajant, H., Mages,J., and Hacker, G. (2004).
    Enhanced basal AP-1 activity and de-regulation of numerous genes in T cells transgenic for a dominant interfering mutant of FADD/MORT1.
    Eur. J. Immunol.,34, 3006-3015.

    Kreuz, S., Siegmund, D., Rumpf,J.J., Samel, D., Leverkus, M., Janssen, O., Hacker, G., Dittrich-Breiholz, O., Kracht, M., Scheurich.,P., and Wajant, H. (2004).
    NFkappaB activation by Fas is mediated through FADD, caspase-8, and P and is inhibited by FLIP.
    J. Cell Biol.,166, 369-380.

    Fotin-Mleczek, M., Henkler, F., Hausser, A., Glauner, H., Samel, D., Graness, A., Scheurich, P., Mauri, D. & Wajant, H. (2004).
    Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation.
    J.Biol. Chem. 279, 677-85.

    Übersichtsarbeiten 2004:

    Wajant, H. (2004). TRAI4 and NFkappaB signaling-a complex relationship.
    Vitam. Horm., 67, 101-132.

    Wajant, H., Scheurich, P. (2004). Analogies betwen Drosophila and mamalian TRAF pathways.
    Prog. Mol. Subcell Bio., 34, 46-72.


    Originalarbeiten 2003:

    Henkler, F., Baumann, B., Fotin-Mleczek, M., Weingärtner, M., Schwenzer, R., Peters, N., Wirth, T., Scheurich, P., Schmid, JA. and Wajant, H. (2003).Caspase-mediated cleavage converts TRAF1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-B activation
    J. Biol. Chem., (epub ahead of print).

    Buhler H., Effenberger F., Forster S., Roos J., and Wajant H. (2003).Substrate Specificity of Mutants of the Hydroxynitrile Lyase from Manihot esculenta.
    ChemBiochem., 4 211-216.

    Übersichtsarbeiten 2003:

    Wajant H., Pfizenmaier, K., and Scheurich P. (2003). Tumor Necrosis Factor.
    Cell Death and Differ., 10 45-65.

    Wajant. H., Pfizenmaier, K., and Scheurich, P. ( 2003). Non-apoptotic Fas signaling
    Cytokine and Growth Factor Rev., 14 53-66.


    Originalarbeiten 2002:

    Siegmund, D., Pfizenmaier, K., Vornlocher, H.-P., and Wajant, H. (2002). Selective inhibition of FLICE-like inhibitory protein (FLIP) expression with shortdouble-stranded RNA oligonucleotides is sufficient to sensitise tumor cells for TRAIL-induced apoptosis.
    Mol. Med., 8 725-732.

    Baumann, B., Bohnenstengel, F., Siegmund, D., Wajant, H., Weber, C., Herr, I., Debatin, K.-M., Proksch, P. and Wirth, T. (2002). Rocaglamide derivatives are potent inhibitors of NF-B activation in T-cells.
    J. Biol. Chem., 277 44791-44800.

    Lauble, H., Miehlich, B., Förster, S., Wajant, H., and Effenberger, F. (2002). Crystal structure of hydroxynitrile lyase from Sorghum bicolor in complex with inhibitor benzoic acid: a novel cyanogenic enzyme.
    Biochemistry, 41 12043-12050.

    Glauner, H., Siegmund, D., Motejadded, H., Scheurich, P., Henkler, F., Janssen, O., and Wajant, H. (2002). Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4).
    Eur. J. Biochem., 269 4819-4829.

    Weingärtner, M., Siegmund, D., Schlecht, U., Fotin-Mleczek, M., Scheurich, P., and Wajant, H. (2002). Endogenous membrane TNF is a potent amplifier of TNF-R1-mediated apoptosis.
    J. Biol. Chem., 277 34853-34859.

    Fotin-Mleczek, M., Henkler, F., Samel D., Reichwein, M., Parmryd, I., Scheurich, P., Schmid, J.A., and Wajant, H. (2002). The combination of TNF-R2-induced TRAF2-depletion and delayed TNF-R1-dependent activation of caspase-8 is the molecular basis of the apoptotic crosstalk of TNF-R1 and TNF-R2.
    J. Cell Sci., 115 2757-2770.

    Oßwald, S., Wajant, H. and Effenberger, F. (2002). Characterization and Synthetic Applications of Recombinant AtNIT1 from Arabidopsis thaliana.
    Eur. J. Biochem., 269 680-687.

    Lauble, H., Miehlich, B., Förster, S., Kobler, C., Wajant, H., and Effenberger, F. (2002). Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta.
    Protein Sci., 11 65-71.

    Übersichtsarbeiten 2002:

    Wajant, H., Pfizenmaier, K., and Scheurich, P. (2002). TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy.
    Apoptosis, 7 449-459.

    Wajant, H. (2002). The Fas signaling pathway: More than a paradigm of death receptor-induced apoptosis.
    Science, 296 1635-1636. Wajant, H. (2002). Fas signaling pathway. Science, Signal Transduction Knowledge Environment.


    Originalarbeiten 2001:

    Siegmund, D., Hausser, A., Peters, N., Scheurich, P., and Wajant, H. (2001). Tumor Necrosis Factor and phorbolester induce TRAIL under critical involvement of NEMO/IKK.
    J. Biol. Chem., 276 43708-43712.

    Siegmund, D., Mauri, D., Peters, N., Juo, P., Thome, M., Reichwein, M., Blenis, J., Scheurich, P., Tschopp, J., and Wajant, H. (2001). FADD and Caspase-8 mediate up-regulation of c-fos by FasL and TRAIL via a FLIP-regulated pathway.
    J. Biol. Chem., 276 32585-32590.

    Wajant, H., Moosmayer, D., Wüest, T., Bartke, T., Gerlach, E., Peters, N., Scheurich, P., and Pfizenmaier, K. (2001). Differential activation requirements of TRAIL-R1 and -2 allows surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivate.
    EMBO J., 18 3034-3043.

    Kreuz, S., Siegmund, D., Scheurich, P., and Wajant, H. (2001). NF-B inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor Signaling.
    J. Biol. Chem., 276 43708-43712.

    Lauble, H., Miehlich, B., Förster, S., Wajant, H., and Effenberger, F. (2001). Mechanistic aspects of cyanogenesis from active-site mutant Ser80Ala of hydroxynitrile lyase from Manihot esculenta in complex with acetone cyanohydrin.
    J. Biol. Chem., 276 32585-32590.

    Bartke, T., Siegmund, D., Peters, N., Reichwein, M., Henkler, F., Scheurich, P., and Wajant, H. (2001). p53 upregulates cFLIP, inhibits transcription of NF-B-regulated genes and induces caspase-8-independent cell death in DLD-1 cells.
    Oncogene, 20 4101-4106.

    Lauble, H., Förster, S., Miehlich, B., Wajant, H., and Effenberger, F. (2001). Crystall structure of hydroxynitrile lyase from Manihot esculenta in complex with substrates acetone and chloroacetone: Implication for the molecular mechanism of cyanogenesis.
    Acta Cryst., D57 194-200.

    Preiss, A., Johannes, B., Peters, N., Nagel, A. C., Maier, D., and Wajant, H. (2001). Dynamic expression of Drosophila TRAF1 during embryogenesis and larval development.
    Mol. Cell. Biol., 21 3964-3973.

    Übersichtsarbeiten 2001:

    Wajant, H., Henkler, F., and Scheurich, P. (2001). The TNF receptor-associated factor (TRAF) family: Scaffold molecules for cytokine receptors, kinases and their regulators.
    Cell. Signal., 13 389-400.

    Wajant, H. and Pfizenmaier, K. (2001). Vom Tumornekrosefaktor zum TRAIL-AMAIZe: Antitumoral wirksame Zytokine der zweiten Generation.
    Onkologie, 24 6-10.

    Wajant, H. and Scheurich, P. (2001). Tumor Necrosis Factor Receptor-associated factor (TRAF) 2 and its role in TNF Signaling.
    Int. J. Biochem. Cell Bio., 33 19-32.


    Originalarbeiten 2000:

    Engels, I. H., Stepczynska, A., Stroh, C., Berg, C., Schwenzer, R., Wajant, H., Jänicke, R. U., Porter, A. G., Belka, C., Gregor, M., Schulze-Osthoff, K., and Wesselborg, S. (2000). Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis.
    Oncogene, 19 4563-4573.

    Mühlenbeck, F., Schneider, P., Bodmer, J.-L., Schwenzer, R., Hausser, A., Schubert, G., Scheurich, P., Moosmayer, D., Tschopp, J., and Wajant, H. (2000). TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation.
    J. Biol. Chem., 275 32208-32213.

    Wajant, H., Haas, E., Schwenzer, R., Mühlenbeck, F., Sebastian Kreuz, Schubert, G., Smith, C., and Scheurich, P. (2000). Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level or upstream of FADD.
    J. Biol. Chem., 275 24357-24366.

    Irmler, M., Martinon, F., Holler, N., Steiner, V., Ruegg, C., Wajant, H. and Tschopp, J. (2000). Activation of a pro-apoptotic amplification loop through inhibition of NF-kappa B-dependent survival signals by caspase-mediated inactivation of TRAF1 and RIP.
    FEBS Lett., 468 129-33.

    Übersichtsarbeiten 2000:

    Schwenzer, R., Zimmermann, G., Fotin, M., Wajant, H., and Grell, M. (2000). No RISC, no fun: assembly of receptor-induced signalling complexes in the tumor necrosis factor system.
    Eur. Cytokine Netw., 11 519-520.

    Effenberger, F., Förster, S., and Wajant, H. (2000). Oxynitrilases in stereoselective catalysis.
    Curr. Opin. Biotechnol., 11 532-539.


    Originalarbeiten 1999:

    Schwenzer, R., Siemienski, K., Liptay, S., Schubert, G., Peters, N., Scheurich, P., Schmid, R., and Wajant, H. (1999). The human TNF receptor associated factor (TRAF) 1 gene is upregulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-B and JNK.
    J. Biol. Chem., 274 19368-19374.

    Haas, E., Grell, M., Wajant, H., and Scheurich, P. (1999). Continous autotropic signaling by membrane expressed tumor necrosis factor.
    J. Biol. Chem., 274 18107-18112.

    Lauble, H., Decanniere, K., Wajant, H., Foerster, S., Effenberger, F. (1999). Crystallization and preliminary X-ray diffraction analysis of hydroxynitrile lyase from cassava (Manihot esculenta).
    Acta Cryst., D55 904-906.

    Grell, M., Zimmermann, G., Gottfried, E., Chen C.-M., Grünwald, U., Huang, D.C.S., Lee Y-H.W. Lee, Dürkop, H., Engelmann, H., Scheurich, P., Wajant, H.*, and Strasser, A*. (1999). *share senior authorship. Induction of cell death by tumor necrosis factor (TNF) receptor 2, CD40 and CD30 - a role for TNF-R1 activation by endogenous membrane-anchored TNF.
    EMBO J., 18 3034-3043.

    Schneider, P., Schwenzer, R., Mühlenbeck, F., Haas, E., Tschopp, J., and Wajant, H. (1999). TWEAK induces cell death via endogenous TNF and TNF-R1.
    Eur. J. Immunol., 29 1785-1792.

    Übersichtsarbeiten 1999:

    Wajant, H., Grell, M., and Scheurich, P (1999). TNF receptor associated factors (TRAF) in cytokine signaling.
    Cytokine and Growth Factor Rev., 10 15-26.


    Originalarbeiten 1998:

    Trummler, K., Roos, J., Schwaneberg, U., Emerich, U., Effenberger, F., Förster, S., Pfizenmaier, K., and Wajant, H. (1998). Expression of the Zn2+-containing hydroxynitrile lyase from flax (Linum usitatissimum) in Pichia pastoris - utilization of the recombinant enzyme for enzymatic analysis and site-directed mutagenesis.
    Plant Science, 139 19-27.

    Mühlenbeck, F., Haas, E., Schwenzer, R., Schubert, G., Grell, M., Smith, C., Scheurich, P., and Wajant, H. (1998). TRAIL activates c-Jun N-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways.
    J. Biol. Chem., 273 33091-33098.

    Johannes, F.J., Horn, J., Link, G., Haas, E., Siemienski, K., Wajant, H., and Pfizenmaier, K. (1998). Protein Kinase C µ downregulates TNF induced apoptosis via enhancement of NF-B dependent protective genes.
    Eur. J. Biochem., 257 47-54.

    Wajant, H., Mühlenbeck, F., and Scheurich, P. (1998). Identification of a TRAF gene in Caenorhabditis elegans.
    J. Mol. Evol., 47 656-662.

    Weiss, T., Grell, M., Siemienski, K., Dürkop, H., Pfizenmaier, K., Scheurich, P., and Wajant, H. (1998). TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TRAF2 and is specific for TNFR60.
    J. Immunol., 161 3136-3142.

    Grell, M., Becke, F. M., Wajant, H., Männel, D. N., and Scheurich, P. (1998). Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1.
    Eur. J. Immunol., 28 257-263.

    Grell, M., Wajant, H., Zimmermann, G., and Scheurich, P. (1998). The typ I receptor (CD120a) is the high affinity receptor for soluble tumor necrosis factor. Proc.
    Natl. Acad. Sci. USA, 95 570-575.

    Wajant, H., Johannes, F.-J., Haas, E., Siemienski, K., Schubert, G., Weiss, T., Grell, M., and Scheurich, P. (1998). A dominant negative mutant of FADD interferes with TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not with NF-B activation and gene induction.
    Curr. Biol., 8 113-116.

    Übersichtsarbeiten 1998:

    Scheurich, P., Pfeffer, K., and Wajant, H. (1998). Tumor necrosis factors in 1998.
    Cytokine and Growth Factor Rev., 9 297-302.


    Originalarbeiten 1997:

    Weiss, T., Grell, M., Hessabi, B., Bourteele, S., Müller, G., Scheurich, P., and Wajant, H. (1997). Enhancement of TNF receptor p-60 mediated cytotoxicity by TNF receptor p80 - Requirement of the TNF receptor-associated factor-2 binding site.
    J. Immunol.,158 2398-2404.

    Trummler, K., and Wajant, H. (1997). Molecular cloning of acetone cyanohydrin lyase from Linum usitatissimum - Definition of a novel class of hydroxynitrile lyases.
    J. Biol. Chem., 272 4770-4774.

    Siemienski, K., Scheurich, P., and Wajant, H. (1997). Organization of the human TNF receptor associated factor (TRAF)1 gene and mapping to chromosome 9q33-34.
    Gene, 195 35-39.


    Originalarbeiten 1996:

    Wajant, H., Förster, S., Sprauer, A., Effenberger, F., and Pfizenmaier, K. (1996). Enantioselective synthesis of aliphatic (S)-cyanohydrins in organic solvents using hydroxynitrile lyase from Manihot esculenta.
    Annals N. Y. Acad. Sci., 799 771-776.

    Wajant, H., and Pfizenmaier, K. (1996). Identification of potential active-site residues in the hydroxynitrile lyase from Manihot esculenta by site-directed mutagenesis.
    J. Biol. Chem., 271 25830-25834.

    Wajant, H., and Förster, S. (1996). Purification and characterization of hydroxynitrile lyase from Hevea brasiliensis.
    Plant Science, 115 25-31.

    Moosmayer, D., Wajant, H., Gerlach, E., Schmidt, M., Brocks, B., and Pfizenmaier, K. (1996). Characterization of different soluble TNF receptor (TNFR80) derivatives: positive influence of the intracellular domain on receptor/ligand interaction and TNF neutralization capacity.
    Lymphokine Cytokine Res., 16 471-477.

    Lauble, H., Knödler, S., Schindelin, H., Förster, S., Wajant, H., and Effenberger, F. (1996). Crystallographic studies and preliminary X-ray investigation of (S)-p-hydroxy-mandelonitrile lyase from Sorghum bicolor (L.).
    Acta Cryst., D52 887-889.

    Hornung, E., Wajant, H., Jeske, H., and Mundry, K.-W. (1996). Cloning of a cDNA encoding a new ribosome-inactivating protein from Beta vulgaris vulgaris (mangold).
    Gene, 170 233-236.

    Förster, S., Roos, J., Effenberger, F., Wajant, H., and Sprauer, A. (1996). The first recombinant hydroxynitrile lyase and its application in the synthesis of (S)-cyanohydrins.
    Angew. Chem. Int. Ed. Engl., 35 437-439.

    Übersichtsarbeiten 1996:

    Wajant, H., and Effenberger, F. (1996) Hydroxynitrile lyases of higher plants.
    Biol. Chem., 377 611-617.

    Pfizenmaier, K., Wajant, H., and Grell, M. (1996). Tumor necrosis factors in 1996.
    Cytokine and Growth Factor Rev., 7 271-277.


    Originalarbeiten 1995:

    Wajant, H., Förster, S., Selmar, D., Effenberger, F., and Pfizenmaier, K. (1995). Purification and characterization of a novel (R)-mandelonitrile lyase from the fern Phlebodium aureum.
    Plant Physiol., 109 1231-1238.

    Wajant, H., Förster, S., Böttinger, H., Effenberger, F., and Pfizenmaier, K. (1995). Acetone cyanohydrin lyase from Manihot esculenta (cassava) is serologically distinct from other hydroxynitrile lyases.
    Plant Science, 108 1-11.

    Grell, M., Douni, E., Wajant, H., Löhden, M., Clauss, M., Maxeiner, B., Georgpoulos, S., Lesslauer, W., Kollias, G., Pfizenmaier, K., and Scheurich, P. (1995). The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor.
    Cell, 83 793-802.

     


     

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